One common theme between all omics applications is the ever-increasing size of patient cohorts, driven by the need for identification of novel disease biomarkers and increasing the power of the studies. However, as these studies scale to thousands of patient samples throughput becomes the limiting factor. It may be possible to decrease separation time, however this comes at the cost of peak capacity and feature detection. Vacuum jacketed columns (VJC) can significantly increase peak capacity and narrow peak widths, thereby allowing faster chromatography when combined with fast scanning acquisitions without information loss, or maintaining chromatography duration while increasing peak capacity.