Desorption electrospray ionization is now an established imaging technique. With all imaging techniques there is a continual drive towards smaller pixel sizes and higher image resolution. Here we demonstrate a low flow DESI technique for high image resolution achieved on a commercially available DESI source setup. With the push to smaller pixel sizes the time to acquire data grows exponentially, even with high acquisition rates of 10-20 pixels / sec analysis times are unsustainable. To help alleviate this problem we describe a time saving, data driven re-acquisition technique which allows detailed high resolution images to be acquired after quick low resolution initial passes.