Liquid chromatography-mass spectrometry (LC-MS) methods have historically been run with optimum instrument parameters for the best sensitivity. To run at these settings, more energy is often required. A move can be made towards developing methods to get optimum sensitivity out of an instrument to meet necessary regulatory levels whilst also saving on the energy needed to run that method. This would provide monetary savings whilst reducing environmental impact.
The Xevo MRT mass Spectrometer has been designed with a focus on sustainability. Instrument design (i.e. materials) and energy consumption were considered. The energy savings associated with the three power modes were designed for use with the Xevo MRT Mass are explored. Additionally, optimisation of method parameters, including desolvation gas flow and temperature also delivered a reduction in both gas and energy consumption without compromising method performance.
The fast-scanning capability (100Hz) of the Xevo MRT was also explored from an energy savings perspective. A lipidomic assay was condensed by 69%, by time and a shorter narrower column employed. This saw solvent consumption reduced by 88%.